About 20 results found for searched term "HCV Protease" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1808 | Telaprevir | HCV Protease |
| VX-950 | ||
| Telaprevir (VX-950) is a novel hepatitis C virus (HCV) NS3-4A protease inhibitor with IC50 of < 0.2 μM. | ||
| M1844 | ITMN-191 | Proteasome |
| Danoprevir, RG7227 | ||
| ITMN-191 (Danoprevir, RG7227) is a potent and orally active inhibitor of hepatitis C virus (HCV) NS3/4A serine protease with an IC50 of 1.6 nM. | ||
| M2727 | GS-9256 | HCV Protease |
| GS-9256 is a novel phosphinic acid derived inhibitor of the HCV NS3/4A protease with IC50 of 4 nM. | ||
| M3624 | Boceprevir (EBP 520) | HCV Protease |
| EBP-520, SCH503034 | ||
| Boceprevir (EBP-520, SCH503034) is an HCV protease inhibitor (Ki=14 nM) for the treatment of hepatitis C virus infection. | ||
| M3627 | Vaniprevir | HCV Protease |
| MK-7009 | ||
| Vaniprevir (MK-7009) is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease. | ||
| M3630 | BILN 2061 | HCV Protease |
| Ciluprevir, BILN 2061ZW | ||
| BILN 2061 is a specific and potent peptidomimetic inhibitor of the HCV NS3 protease with IC50 of 3.0 nM. | ||
| M3680 | GS-9451 | HCV Protease |
| GS-9451, a novel hepatitis C virus (HCV) nonstructural 3/4a (NS3/4a) protease inhibitor, is highly active in patients infected with HCV genotype 1 (GT 1). | ||
| M20529 | Glecaprevir | HCV Protease |
| Glecaprevir is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor that targets the the viral RNA replication. It displays IC50 values ranging from 3.5 to 11.3 nM for clinical isolates of HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a. | ||
| M21642 | Voxilaprevir (GS-9857) | HCV Protease |
| GS-9857 | ||
| Voxilaprevir (GS-9857) is a noncovalent, reversible inhibitor of HCV NS3/4A protease inhibitor (PI) with pangenotypic antiviral activity. Voxilaprevir inhibits genotype 1b and 3a wild-type NS3 proteases with Ki values of 0.038 nM and 0.066 nM, respectively. | ||
| M27626 | HZ-1157 | Anti-infection |
| HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent. | ||
| M27921 | BI 653048 | GCR |
| BI 653048 is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM. BI 653048 inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM). BI 653048 is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus. | ||
| M27922 | BI 653048 phosphate | GCR |
| BI 653048 phosphate is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM. BI 653048 phosphate inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM). BI 653048 phosphate is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus. | ||
| M30685 | BI-1230 | Anti-infection |
| BI-1230 is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity. | ||
| M30743 | Narlaprevir | Anti-infection |
| SCH 900518 | ||
| Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a Ki value of 6 nM and an EC90 value of 40 nM. Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease. Narlaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.3 μM. | ||
| M38751 | Isoeuphorbetin | HCV Protease |
| Isoeuphorbetin, a dimeric coumarin isolated from Viola philippica, is a potent HCV protease inhibitor with an IC50 of 3.63 µg/mL. | ||
| M51387 | Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 | Others |
| Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 (HCV NS3 protease substrate) is a biological active peptide. | ||
| M53494 | Hepatitis Virus C NS3 Protease Inhibitor 2 | HCV Protease |
| Hepatitis Virus C NS3 Protease Inhibitor 2 is a product-based peptide inhibitor of hepatitis C virus (HCV) NS3 protease, with a Ki of 41 nM. | ||
| M53495 | Ac-EEVVAC-pNA | HCV Protease |
| Ac-EEVVAC-pNA is a chromogenic substrate for a continuous spectrophotometric assay of HCV NS3 protease. | ||
| M53496 | Ac-D-DGla-LI-Cha-C | HCV Protease |
| Ac-D-DGla-LI-Cha-C is a potent HCV protease inhibitor peptide. | ||
| M53506 | HCV NS4A Protein (18-40) (JT strain) | Anti-infection |
| HCV NS4A Protein (18-40) (JT strain) is an HCV NS4A peptide, which comprised residues 18 to 40 of the NS4A protein and is known to increase the catalytic efficiency of NS3 protease. | ||
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